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Orthobiologics

SynerG™ Orthobiologics

Outcome-Tracked Biologic Therapy, Delivered with Precision
Biologic treatments shouldn’t feel vague or experimental. SynerG™ at SIGMA Orthopedic and Sports Medicine brings structure to orthobiologics, standardizing preparation, image-guided delivery, and progress tracking through Patient-Reported Outcomes (PROs). The result is clarity at every step: what treatment is being used, why it’s being recommended, and how results will be measured over time.
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What to Know About Orthobiologics

Orthobiologics are treatments made from your own blood, bone marrow, or adipose tissue, or from purified proteins that may help decrease inflammation, support tissue recovery, and improve pain. The SynerG™ process applies Six Sigma discipline to each step, clinical selection, preparation protocols, image-guided injection technique, and outcomes tracking, to support more consistent decision-making and long-term care planning.

Who This For

  • Tendonitis and small, low-grade tendon tears
  • Cartilage injuries and focal chondral defects
  • Joint pain and mild to moderate knee osteoarthritis

Treatment Options Offered

ACP (Autologous Conditioned Plasma):

Concentrated plasma derived from your blood; often considered for tendon discomfort and select joint concerns.

PRP (Platelet-Rich Plasma):

Platelet concentrate prepared using defined spin protocols; typically delivered with ultrasound guidance for accuracy.

A2M (Alpha-2-Macroglobulin):

A naturally occurring protease inhibitor; considered when inflammation may be driven by enzyme activity.

Adipose-Derived Cell Preparations:

Adipose tissue is harvested and processed; candidacy and regulatory considerations are discussed during evaluation.

BMAC (Bone Marrow–Derived Cell Preparations):

Bone marrow aspirate concentrate is considered selectively for certain tendon or cartilage conditions through shared decision-making.

The SynerG™ Protocol

Step 01
Clinical Review & Imaging

Confirm the diagnosis and evaluate imaging; ultrasound may be used to plan targeting.

Step 02
Standardized Processing

Defined kits and spin times, with documented tracking for consistency.

Step 03
Ultrasound-Guided Placement

Real-time visualization helps deliver treatment to the intended tissue.

Step 04
Recovery Support Resources

Recovery tools may include cryotherapy, TENS, and nutrition optimization to reduce discomfort and support healing.

Step 05
Outcome Monitoring

Enroll in PRO tracking with benchmarks and follow-ups to measure real changes in function and symptoms.

Coverage & Safety Notes 

Biologic treatments differ in insurance coverage and regulatory status. Benefits, risks, costs, and alternatives are reviewed clearly so decisions are informed and confident.

FREQUENTLY ASKED QUESTIONS

Does insurance cover these treatments?
Coverage varies by the specific biologic option and the medical indication. Some plans may cover parts of the visit or imaging, while the biologic itself may be self-pay. Expected costs and payment details are reviewed clearly before moving forward.
It depends on the condition, severity, and response to treatment. Some patients are candidates for a single injection, while others may benefit from a planned series. The recommendation is based on diagnosis, goals, and measurable progress over time.
In many cases, yes. Ultrasound guidance improves accuracy by targeting the intended tissue in real time, which can help with consistency and confidence in delivery, especially for tendon, joint, and soft-tissue targets.
Most patients have minimal downtime, but a short period of activity modification is common. Heavy lifting, high-impact training, or intense sport may be limited temporarily while symptoms settle and the recovery plan progresses.
If improvement is limited, the next step is a structured reassessment, reviewing diagnosis, biomechanics, load management, and objective outcomes. Options may include adjusting rehab strategy, considering alternate treatments, or discussing procedural or surgical solutions when appropriate.

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